Evidence of direct smooth muscle relaxant effects of the fibrate gemfibrozil
نویسندگان
چکیده
منابع مشابه
Evidence of direct smooth muscle relaxant effects of the fibrate gemfibrozil.
Fibrates are commonly employed to treat abnormal lipid metabolism via their unique ability to stimulate peroxisome proliferator-activated receptor alpha (PPARalpha). Interestingly, they also decrease systemic arterial pressure, despite recent evidence that PPAR alpha may contribute to expression of renin and related hypertension. Yet, mechanisms responsible for their potential antihypertensive ...
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We sought to determine direct vascular effects of peroxisome proliferator-activated receptor alpha (PPARα) agonists using isolated mouse aortas and middle cerebral arteries (MCAs). The PPARα agonists GW7647, WY14643, and gemfibrozil acutely relaxed aortas held under isometric tension and dilated pressurized MCAs with the following order of potency: GW7647≫WY14643>gemfibrozil. Responses were end...
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ژورنال
عنوان ژورنال: Journal of Smooth Muscle Research
سال: 2010
ISSN: 0916-8737,1884-8796
DOI: 10.1540/jsmr.46.125